Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents
نویسندگان
چکیده
منابع مشابه
Synthesis and anticancer activity assay of novel chalcone sulfonamide derivatives
Chalcones, or 1,3–diaryl–2–propen–1–ones, one of the major classes of natural products and posses many useful properties like anticancer, antibacterial, antifungal, anti–inflammatory, antimalarial and anti–diabetic activity. We report in this communication the synthesis and anticancer study of a number of novel chalcone sulfonamides. Our results indicate that the synthesis of chalcone sulfonami...
متن کاملSynthesis and anticancer activity assay of novel chalcone sulfonamide derivatives
Chalcones, or 1,3–diaryl–2–propen–1–ones, one of the major classes of natural products and posses many useful properties like anticancer, antibacterial, antifungal, anti–inflammatory, antimalarial and anti–diabetic activity. We report in this communication the synthesis and anticancer study of a number of novel chalcone sulfonamides. Our results indicate that the synthesis of chalcone sulfonami...
متن کاملSynthesis and In-vitro Evaluation of Copolyester- Chalcone Derivatives as Potential Anticancer Agents
A new series of copolyester chalcone derivatives were synthesised from 1, 3-bis (4-hydroxy-3methoxyphenyl) propenone (BHMPP) and 1(3, 5-dihydroxyphenyl)-3-(4-methoxyphenyl) propenone (DHPMPP) with adipoyl, suberoyl, azeloyl and sebacoyl chlorides by phase transfer catalysed polycondensation method. The microstructure of the repeating unit was confirmed by IR, 1 H and 13 C NMR. These copolyester...
متن کاملSynthesis and Anticancer Activity Assay of Novel Chalcone-Sulfonamide Derivatives
Today Cancer remains to be one of the most deadly diseases in the world. Due to the potential anticancer activity of the chalcone and sulfonamide moieties, five novel hybrid compounds containing both structures have been designed and synthesized in 3 steps. The synthesized compounds were established on the basis of IR, 1H NMR, 13C NMR spectral data, and elemental analysis and also they were scr...
متن کاملSynthesis and Evaluation of Bakuchiol Derivatives as Potential Anticancer Agents.
A series of bakuchiol derivatives were synthesized and evaluated for their anti-proliferative and the inhibitory activities on SMMC7721 cell line migration using PX-478 as a positive control. The results showed (S,E)-4-(7-methoxy-3,7-dimethyl-3-vinyloct-1-en-1-yl)phenol (10) to have the best activity among the tested compounds, which included PX-478. In addition, compound 10 showed greater inhi...
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ژورنال
عنوان ژورنال: Saudi Pharmaceutical Journal
سال: 2017
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2016.06.005